Trace metals and the hemostatic system

F Marongiu; S Marongiu; M F Ruberto; G Faa; D Barcellona

doi:10.1016/j.cca.2023.117458

Trace metals and the hemostatic system

Clin Chim Acta. 2023 Jul 1:547:117458. doi: 10.1016/j.cca.2023.117458. Epub 2023 Jun 28.

Authors

F Marongiu¹, S Marongiu², M F Ruberto³, G Faa⁴, D Barcellona⁵

Affiliations

¹ Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy; Haemostasis and Thrombosis Unit, Azienda Ospedaliero-Universitaria (A.O.U.), Cagliari, Cagliari, Italy; Fondazione Arianna, Anticoagulazione.it, Bologna, Italy.
² Department of Medicine, Azienda Tutela della Salute Cagliari, Cagliari, Italy.
³ Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy; Haemostasis and Thrombosis Unit, Azienda Ospedaliero-Universitaria (A.O.U.), Cagliari, Cagliari, Italy.
⁴ Department of Medical Sciences and Public Health, Division of Pathology, Azienda Ospedaliero-Universitaria (A.O.U.), di Cagliari - University Hospital San Giovanni di Dio, University of Cagliari, Cagliari, Italy; Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA.
⁵ Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy; Haemostasis and Thrombosis Unit, Azienda Ospedaliero-Universitaria (A.O.U.), Cagliari, Cagliari, Italy; Fondazione Arianna, Anticoagulazione.it, Bologna, Italy. Electronic address: doris.barcellona@unica.it.

PMID: 37385467
DOI: 10.1016/j.cca.2023.117458

Abstract

In this narrative review we report the main relationships between trace metals and the hemostatic system since this aspect has seldom attracted the attention of the scientific community. A basic aspect to be considered is the importance of maintaining the fine control of all trace metals' levels since they have an important impact on the pathophysiology of the hemostatic system. It is worth noting that poor diet habits are responsible for most trace metal deficiencies, while pollution is responsible for dangerous exposure to them with a consequent negative impact on the general population. This appears of paramount importance in planning the implementation of food and nutrient support to ameliorate the hidden hunger and the quality of life of people especially in developing countries and limiting poisons both in the air and food. As it often happens, when damage to certain mechanisms takes a very long time to appear, no attention is paid to the importance of a systematic prevention to avoid late negative outcomes.

Keywords: Cadmium; Calcium; Haemostasis; Iron; Magnesium; Thrombosis; Zinc.

Publication types

Review

MeSH terms

Cadmium
Hemostatics*
Humans
Quality of Life
Trace Elements*
Zinc

Substances

Zinc
Hemostatics
Cadmium
Trace Elements