Patients with a facial malformation due to a cleft lip and palate (CLP) usually suffer from a reduced ability to function normally associated with a poor oral health-related quality of life. This condition often requires multiple significant surgical interventions, and the prosthetic restoration, when needed, is not always included in the initial treatment plan. In order to obtain the highest possible degree of functional, occlusal, and phonetic performance, as well as esthetics, a facially guided prosthodontic treatment sequence should be established. The case presented in this publication shows a multidisciplinary approach for reconstruction of a compromised maxilla with an implant-supported prosthesis via a minimally invasive, digitalized approach.