Tissue engineering has become one of the most studied medical fields and appears to be promising for the regeneration of injured bone tissues. Even though the bone has self-remodeling properties, bone regeneration may be required in some cases. Current research concerns materials employed to develop biological scaffolds with improved features as well as complex preparation techniques. Several attempts have been made to achieve compatible and osteoconductive materials with good mechanical strength in order to provide structural support. The application of biomaterials and mesenchymal stem cells (MSCs) is a promising prospect for bone regeneration. Recently, various cells have been utilized alone or in combination with biomaterials to accelerate bone repair in vivo. However, the question of what cell source is the best for use in bone engineering remains open. This review focuses on studies that evaluated bone regeneration using biomaterials with MSCs. Different types of biomaterials for scaffold processing, ranging from natural and synthetic polymers to hybrid composites, are presented. These constructs demonstrated an enhanced ability to regenerate the bone in vivo using animal models. Additionally, future perspectives in tissue engineering, such as the MSC secretome, that is the conditioned medium (CM), and the extracellular vesicles (EVs), are also described in this review. This new approach has already shown promising results for bone tissue regeneration in experimental models.
Keywords: materials; secretome; stem cells; tissue engineering.