Ratiometric photoacoustic imaging of endogenous HNO in vivo for assessing prodrug release and liver injury

Xiaopeng Fan; Hongzhen Wang; Wen Yang; Tianbing Ren; Lin Yuan

doi:10.1039/d3cc02857g

Ratiometric photoacoustic imaging of endogenous HNO in vivo for assessing prodrug release and liver injury

Chem Commun (Camb). 2023 Jul 18;59(58):8969-8972. doi: 10.1039/d3cc02857g.

Authors

Xiaopeng Fan^{1

2}, Hongzhen Wang¹, Wen Yang², Tianbing Ren², Lin Yuan²

Affiliations

¹ State Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Materials Science, Hebei University, Baoding 071002, P. R. China. xiaopengfan@hbu.edu.cn.
² State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China. rentianbing@hnu.edu.cn.

PMID: 37381946
DOI: 10.1039/d3cc02857g

Abstract

The effective imaging of endogenous HNO is highly crucial for pathology research and medical development due to its important pharmacological activity in biological systems. Here, a ratiometric photoacoustic probe in response to HNO was rationally developed to effectively assess HNO prodrug release and liver injury in vivo.

MeSH terms

Fluorescent Dyes
Liver / diagnostic imaging
Nitrogen Oxides
Optical Imaging / methods
Photoacoustic Techniques* / methods
Prodrugs* / pharmacology

Substances

Nitrogen Oxides
Fluorescent Dyes
Prodrugs