Immunometabolism and immune response regulate macrophage function in atherosclerosis

Sheng Xue; Zhe Su; Dacheng Liu

doi:10.1016/j.arr.2023.101993

Immunometabolism and immune response regulate macrophage function in atherosclerosis

Ageing Res Rev. 2023 Sep:90:101993. doi: 10.1016/j.arr.2023.101993. Epub 2023 Jun 27.

Authors

Sheng Xue¹, Zhe Su², Dacheng Liu²

Affiliations

¹ Institute of Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266003 China. Electronic address: shengxue@qdu.edu.cn.
² Institute of Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266003 China.

PMID: 37379970
DOI: 10.1016/j.arr.2023.101993

Abstract

Macrophages are crucial in the progression of atherosclerotic cardiovascular disease (ASCVD). In the atherosclerotic lesions, macrophages play a central role in maintaining inflammatory response, promoting plaque development, and facilitating thrombosis. Increasing studies indicate that metabolic reprogramming and immune response mediate macrophage functional changes in all stages of atherosclerosis. In this review article, we explain how metabolic changes in glycolysis, oxidative phosphorylation, the tricarboxylic acid cycle, fatty acid synthesis, fatty acid oxidation, and cholesterol metabolism regulate macrophage function in atherosclerosis. We discuss how immune response to oxidized lipids regulate macrophage function in atherosclerosis. Additionally, we explore how abnormal metabolism leads to macrophage mitochondrial dysfunction in atherosclerosis.

Keywords: Atherosclerosis; Immune response; Immunometabolism; Macrophage; Oxidation-specific epitopes.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Atherosclerosis* / pathology
Fatty Acids
Humans
Immunity
Macrophages
Plaque, Atherosclerotic* / metabolism

Substances

Fatty Acids