Counterfeit products have infiltrated numerous regions worldwide, causing substantial damage to the financial interests of individuals, businesses, and countries. Moreover, counterfeit goods can pose a severe risk to human health. Therefore, it is crucial to develop effective anti-counterfeiting methods and authentication technologies. Persistent luminescence (PersL) materials show great potential for anti-counterfeiting applications due to their distinctive spatial and temporal dynamic spectrum performance. The unique luminescence properties of PersL materials enable the creation of optical codes with high capacity. In this perspective, we provide a summary of the latest advancements in anti-counterfeiting technology using long persistent phosphors. We discuss the various construction strategies of optical codes for anti-counterfeiting, which include multicolor luminescence, orthogonal luminescence, dynamic luminescence, and stimulus-response luminescence. In addition, we explore the mechanisms of PersL-based anti-counterfeiting materials and consider potential areas for future development to expand the applications of persistent phosphors.