Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems

Yuhki Yanase; Daiki Matsubara; Shunsuke Takahagi; Akio Tanaka; Koichiro Ozawa; Michihiro Hide

doi:10.3390/ijms241210320

Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems

Int J Mol Sci. 2023 Jun 19;24(12):10320. doi: 10.3390/ijms241210320.

Authors

Yuhki Yanase¹, Daiki Matsubara², Shunsuke Takahagi², Akio Tanaka², Koichiro Ozawa¹, Michihiro Hide^{2

3}

Affiliations

¹ Department of Pharmacotherapy, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 739-0046, Japan.
² Department of Dermatology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 739-0046, Japan.
³ Hiroshima City Hiroshima Citizens Hospital, Hiroshima 730-8518, Japan.

Abstract

Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch and pruritus anywhere on the body for more than 6 weeks. Although basophil- and mast cell-released inflammatory mediators, such as histamine, play important roles in the pathogenesis of CSU, the detailed underlying mechanism is not clear. Since several auto-antibodies, IgGs which recognize IgE or the high-affinity IgE receptor (FcεRI) and IgEs against other self-antigens, are detected in CSU patients, they are considered to activate both mast cells in the skin and basophils circulating in the blood. In addition, we and other groups demonstrated that the coagulation and complement system also contribute to the development of urticaria. Here, we summarized the behaviors, markers and targets of basophils in relation to the coagulation-complement system, and for the treatment of CSU.

Keywords: autoantibody; basophil; biomarker; chronic spontaneous urticaria (CSU); coagulation; complement; histamine; mast cell.

Publication types

Review

MeSH terms

Basophils
Chronic Disease
Chronic Urticaria*
Complement System Proteins
Humans
Receptors, IgE
Skin
Urticaria* / etiology

Substances

Receptors, IgE
Complement System Proteins

Grants and funding

The Study was partially funded by grants to Y.Y. from Takeda Science Foundation, Japanese Society of Allergology Clinical Research Support Program, The Mochida Memorial Foundation for Medical and Pharmaceutical Research, Grant-in-Aid for Scientific Research (C), JST-CREST Japan (Grant Number JPMJCR2016) and to M.H. from Grant-in-Aid for Scientific Research (C).