In order to improve the clinical application of hyperspectral technology in the pathological diagnosis of tumor tissue, a joint diagnostic method based on spectral-spatial transfer features was established by simulating the actual clinical diagnosis process and combining micro-hyperspectral imaging with large-scale pathological data. In view of the limited sample volume of medical hyperspectral data, a multi-data transfer model pre-trained on conventional pathology datasets was applied to the classification task of micro-hyperspectral images, to explore the differences in spectral-spatial transfer features in the wavelength of 410-900 nm between tumor tissues and normal tissues. The experimental results show that the spectral-spatial transfer convolutional neural network (SST-CNN) achieved a classification accuracy of 95.46% for the gastric cancer dataset and 95.89% for the thyroid cancer dataset, thus outperforming models trained on single conventional digital pathology and single hyperspectral data. The joint diagnostic method established based on SST-CNN can complete the interpretation of a section of data in 3 min, thus providing a new technical solution for the rapid diagnosis of pathology. This study also explored problems involving the correlation between tumor tissues and typical spectral-spatial features, as well as the efficient transformation of conventional pathological and transfer spectral-spatial features, which solidified the theoretical research on hyperspectral pathological diagnosis.
Keywords: deep learning; hyperspectral imaging; joint diagnosis; spectral-spatial transfer feature; tumor tissue.