The NLRP3 inflammasome: contributions to inflammation-related diseases

Ying Chen; Xingyan Ye; Germaine Escames; Wangrui Lei; Xin Zhang; Meng Li; Tong Jing; Yu Yao; Zhenye Qiu; Zheng Wang; Darío Acuña-Castroviejo; Yang Yang

doi:10.1186/s11658-023-00462-9

The NLRP3 inflammasome: contributions to inflammation-related diseases

Cell Mol Biol Lett. 2023 Jun 27;28(1):51. doi: 10.1186/s11658-023-00462-9.

Authors

Ying Chen^#¹, Xingyan Ye^#^{2

3}, Germaine Escames^#^{4

5

6}, Wangrui Lei^{2

3}, Xin Zhang⁷, Meng Li⁷, Tong Jing⁷, Yu Yao^{2

3}, Zhenye Qiu^{2

3}, Zheng Wang⁸, Darío Acuña-Castroviejo^{9

10

11}, Yang Yang^{12

13}

Affiliations

¹ Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
² Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.
³ Department of Neurology, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, China.
⁴ Biomedical Research Center, Health Sciences Technology Park, University of Granada, Avda. del Conocimiento s/n, Granada, Spain.
⁵ Ibs. Granada and CIBERfes, Granada, Spain.
⁶ UGC of Clinical Laboratories, University San Cecilio's Hospital, Granada, Spain.
⁷ Department of Cardiology, Affiliated Hospital, Yan'an University, Yan'an, China.
⁸ Department of Cardiothoracic Surgery, Central Theater Command General Hospital of Chinese People's Liberation Army, Wuhan, China.
⁹ Biomedical Research Center, Health Sciences Technology Park, University of Granada, Avda. del Conocimiento s/n, Granada, Spain. dacuna@ugr.es.
¹⁰ Ibs. Granada and CIBERfes, Granada, Spain. dacuna@ugr.es.
¹¹ UGC of Clinical Laboratories, University San Cecilio's Hospital, Granada, Spain. dacuna@ugr.es.
¹² Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China. yang200214yy@nwu.edu.cn.
¹³ Department of Neurology, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, China. yang200214yy@nwu.edu.cn.

^# Contributed equally.

Abstract

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, including arthritis, Alzheimer's disease, inflammatory bowel disease, and other autoimmune and autoinflammatory diseases. This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role of the NLRP3 inflammasome in various inflammation-related diseases. Finally, we look forward to new methods for targeting the NLRP3 inflammasome to treat inflammation-related diseases, and provide new ideas for clinical treatment.

Keywords: Inflammatory disease; Innate immunity; NLRP3 inflammasome.

Publication types

Review

MeSH terms

Humans
Immunity, Innate
Inflammasomes* / metabolism
Inflammation
Interleukin-1beta / metabolism
NLR Family, Pyrin Domain-Containing 3 Protein* / metabolism
NLR Proteins

Substances

Inflammasomes
Interleukin-1beta
NLR Family, Pyrin Domain-Containing 3 Protein
NLR Proteins
NLRP3 protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding