Differential expression of KCNQ1 and ATP4A genes according to the sex and age in the stomach

Azadeh Haddadi; Pegah Farhadi; Raziyeh Fatemi; Parisa Mohamadynejad; Mehdi Moghanibashi

doi:10.1080/15257770.2023.2228371

Differential expression of KCNQ1 and ATP4A genes according to the sex and age in the stomach

Nucleosides Nucleotides Nucleic Acids. 2023;42(12):1019-1027. doi: 10.1080/15257770.2023.2228371. Epub 2023 Jun 27.

Authors

Azadeh Haddadi¹, Pegah Farhadi¹, Raziyeh Fatemi¹, Parisa Mohamadynejad¹, Mehdi Moghanibashi²

Affiliations

¹ Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
² Department of Genetics, Faculty of Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran.

PMID: 37367232
DOI: 10.1080/15257770.2023.2228371

Abstract

We compared the expression of six genes in stomach tissue samples between healthy men and women in different age groups to study sexually dimorphic gene expression. Real-Time RT-PCR was used to compare gene expression between men and women. Our results showed that the expression of KCNQ1 (p = 0.01) was significantly higher in non-menopausal women compared to post-menopausal women. In addition, the expression level of the ATP4A gene in men under 35 years was significantly higher than in men above 50 (p = 0.026). Sexually and age dimorphic gene expression in some genes throughout life may affect gastric function.

Keywords: ATP4A; KCNQ1; Sexual dimorphism; gastric cancer; stomach.

MeSH terms

Female
Gastric Mucosa* / metabolism
H(+)-K(+)-Exchanging ATPase / genetics
H(+)-K(+)-Exchanging ATPase / metabolism
Humans
KCNQ1 Potassium Channel* / genetics
KCNQ1 Potassium Channel* / metabolism
Male
Stomach

Substances

KCNQ1 Potassium Channel
KCNQ1 protein, human
ATP4A protein, human
H(+)-K(+)-Exchanging ATPase