The application of covalent organic frameworks (COFs) in fluorescence detection is of great interest. Herein, we have synthesized the ionic covalent organic framework TGH+·PD: Eu(TTA)4 with the characteristic emission of lanthanides by a straightforward ion-exchange method. This is the first time that aristolochic acid A (AA), a key biomarker for absorption and metabolism in the body for early diagnosis of diseases, has been detected by using COF as a fluorescent probe, which exhibits a good linear correlation with the AA concentration over a range from 5.0 to 1000 μM with a detection limit of 0.0808 μM. In addition, the selective response to sulfamethoxazole (SMZ)/trimethoprim (TMP) is achieved by varying the excitation wavelength with detection lines of 30.2 nM and 2.898 μM, respectively. It is worth mentioning that BNPP has been developed for the accurate determination of SMZ in uncertain samples. In a word, the prepared TGH+·PD: Eu(TTA)4-based sensor can be used for the quantitative detection of AA and SMZ/TMP, separately, effectively extending the application of COFs in the field of fluorescence sensing.
Keywords: Aristolochic acid A; Dual mode response; Ionic covalent organic frameworks; Post-synthetic modification; Sulfamethoxazole; Trimethoprim.
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