Linezolid-induced black hairy tongue in a patient treated for idiopathic granulomatous mastitis: a case report

Ann Med Surg (Lond). 2023 May 10;85(6):3090-3093. doi: 10.1097/MS9.0000000000000834. eCollection 2023 Jun.

Abstract

Linezolid-induced black hairy tongue (BHT) is a highly scarce adverse event of linezolid therapy. To date, there are very few reported cases in contemporary literature. The onset and mechanism of BHT are also not well understood.

Case report: In this article, the authors report a case of BHT in a 28-year-old female following 5 days of therapy with linezolid. The patient recovered well within few days of discontinuation of the drug and maintaining oral hygeine. Patient reassurance and counselling was integral to the management.

Discussion and conclusion: This case report and review depict a rare adverse effect of linezolid and discuss its clinical implications aiding healthcare professionals in an early diagnosis and cromulent management strategy. The authors also present a compilation of previously reported literature on linezolid-induced BHT to support the discussion.

Keywords: Adverse event; antimicrobialbht; black hairy tongue; drug-induced; linezolid.