The Role of DNA Viruses in Human Cancer

Zohreh-Al-Sadat Ghoreshi; Hamid Reza Molaei; Nasir Arefinia

doi:10.1177/11769351231154186

The Role of DNA Viruses in Human Cancer

Cancer Inform. 2023 Jun 13:22:11769351231154186. doi: 10.1177/11769351231154186. eCollection 2023.

Authors

Zohreh-Al-Sadat Ghoreshi¹, Hamid Reza Molaei², Nasir Arefinia¹

Affiliations

¹ Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran.
² Department of Medical Bacteriology and Virology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Abstract

This review discusses the possible involvement of infections-associated cancers in humans, with virus infections contributing 15% to 20% of total cancer cases in humans. DNA virus encoded proteins interact with host cellular signaling pathways and control proliferation, cell death and genomic integrity viral oncoproteins are known to bind cellular Deubiquitinates (DUBs) such as cyclindromatosis tumor suppressor, ubiquitin-specific proteases 7, 11, 15 and 20, and A-20 to improve their intracellular stability and cellular signaling pathways and finally transformation. Human papillomaviruses (cervical carcinoma, oral cancer and laryngeal cancer); human polyomaviruses (mesotheliomas, brain tumors); Epstein-Barr virus (B-cell lymphoproliferative diseases and nasopharyngeal carcinoma); Kaposi's Sarcoma Herpesvirus (Kaposi's Sarcoma and primary effusion lymphomas); hepatitis B (hepatocellular carcinoma (HCC)) cause up to 20% of malignancies around the world.

Keywords: DNA viruses; cancer; oncogenic viruses.

Publication types

Review