Extended-spectrum beta-lactamase in Escherichia coli isolated from humans, animals, and environments in Bangladesh: A One Health perspective systematic review and meta-analysis

Md Saiful Islam; A M M Taufiquer Rahman; Jayedul Hassan; Md Tanvir Rahman

doi:10.1016/j.onehlt.2023.100526

Extended-spectrum beta-lactamase in Escherichia coli isolated from humans, animals, and environments in Bangladesh: A One Health perspective systematic review and meta-analysis

One Health. 2023 Mar 11:16:100526. doi: 10.1016/j.onehlt.2023.100526. eCollection 2023 Jun.

Authors

Md Saiful Islam¹, A M M Taufiquer Rahman², Jayedul Hassan¹, Md Tanvir Rahman¹

Affiliations

¹ Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.
² Naogaon District Hospital, Naogaon 6500, Bangladesh.

Abstract

Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli has been linked to both life-threatening hospital- and community-acquired infections across the globe. Here, we conducted a systematic review and meta-analysis to evaluate the prevalence of ESBL in E. coli isolated from humans, animals, and environments in Bangladesh. Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, the current systematic review and meta-analysis was taken into account for studies published between 2010 and 2021 in peer-reviewed journals. The meta-analysis was performed on "R" version 4.2.2. A total of 36 studies were included in this systematic review and meta-analysis; among them, 22 were human, seven were animal, four were environmental, and three were multidisciplinary studies. The meta-analysis revealed that the pooled prevalence of ESBL-producing E. coli in Bangladesh was 21% (95% CI: 15%-27%). On the sample basis, the pooled prevalence of ESBL-producing E. coli in humans, animals, and environments was 17% (95% CI: 11%-23%), 22% (95% CI: 9%-34%), and 39% (95% CI: 16%-62%), respectively. All the pooled prevalence of ESBL-producing E. coli showed substantial heterogeneity (I² > 75%; p < 0.05) among the selected studies. This systematic review reported 13 different types of resistance genes encoding ESBL, such as bla_TEM-1 (37.5%), bla_CMY (34.6%), bla_CTX-M-1 (20.7%), bla_CTX-M-15 (16.1%), bla_TEM (12.3%), bla_CTX-M and bla_OXA (9.6%), bla_OXA-1 (5.8%), bla_ampC (3.9%), bla_SHV (3.8%), bla_CMY-2 (2.3%), bla_CTX-M-14 (1.3%), and bla_CTX-M-9 (0.3%). Moreover, 39 types of epidemiologically important clones (including ST10 and ST131) were detected in ESBL-producing E. coli isolated from humans, animals, and environments in Bangladesh. To the best of our knowledge, this is the first systematic review and meta-analysis of integrated studies on ESBL-producing E. coli using the One Health approach in Bangladesh. The high prevalence of ESBL-producing E. coli, their resistance genes, and epidemiologically important clones in humans, animals, and environments highlights the importance of implementing comprehensive antimicrobial resistance (AMR) surveillance under a One Health perspective to mitigate the AMR consequences in Bangladesh.

Keywords: Bangladesh; Clones; E. coli; ESBL; One Health; ST10; ST131; blaCTX-M; blaTEM.

Publication types

Review