The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta-analysis and systematic review

Xiaolong Chen; Shibao Lu; Neha Chopra; Peng Cui; Sitao Zhang; Rajpal Narulla; Ashish D Diwan

doi:10.1002/jsp2.1244

The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta-analysis and systematic review

JOR Spine. 2023 Feb 16;6(2):e1244. doi: 10.1002/jsp2.1244. eCollection 2023 Jun.

Authors

Xiaolong Chen^{1

2}, Shibao Lu², Neha Chopra^{1

3}, Peng Cui², Sitao Zhang², Rajpal Narulla¹, Ashish D Diwan^{1

3}

Affiliations

¹ Spine Labs, St. George & Sutherland Clinical School University of New South Wales Sydney New South Wales Australia.
² Department of Orthopaedics Xuanwu Hospital Capital Medical University Beijing China.
³ Spine Service, Department of Orthopaedic Surgery St. George Hospital Campus Sydney New South Wales Australia.

Abstract

Many factors may trigger intervertebral disc (IVD) structural failure (intervertebral disc degeneration (IDD) and endplate changes), including inflammation, infection, dysbiosis, and the downstream effects of chemical factors. Of these, microbial diversity in the IVD and elsewhere in the body has been considered as one of the potential reasons for disc structural failure. The exact relationships between microbial colonization and IVD structural failure are not well understood. This meta-analysis aimed to investigate the impact of microbial colonization and its location (such as skin, IVD, muscle, soft tissues, and blood) on IVD structural failure and corresponding low back pain (LBP) if any. We searched four online databases for potential studies. The potential relationships between microbial colonization in different sample sources (such as skin, IVD, muscle, soft tissues, and blood) and IDD and endplate change were considered as primary outcomes. Odds ratio (OR) and 95% confidence intervals (CI) for direct comparisons were reported. Grading of Recommendations Assessment, Development and Evaluation (GRADE) scale was used to assess the quality of evidence. Twenty-five cohort studies met the selection criteria. Overall pooled prevalence of microbial colonization in 2419 patients with LBP was 33.2% (23.6%-43.6%). The pooled prevalence of microbial colonization in 2901 samples was 29.6% (21.0%-38.9%). Compared with the patients without endplate change, the patients with endplate changes had higher rates of microbial colonization of disc (OR = 2.83; 95% CI = 1.93-4.14; I ² = 37.6%; p = 0.108). The primary pathogen was Cutibacterium acnes which was present in 22.2% of cases (95% CI = 13.3%-32.5%; I ² = 96.6%; p = 0.000). This meta-analysis and systematic review found low-quality grade evidence for an association between microbial colonization of disc with endplate changes. The primary pathogen was C. acnes. Due to lack of enough high-quality studies and methodological limitations of this review, further studies are required to improve our understanding of the potential relationships and mechanisms of microbiota, dysbiosis, IVD colonization and IVD structural failure.

Keywords: back Pain; disc degeneration; meta‐analysis; microbiome; microbiome dysbiosis; systematic review.

Publication types

Review