Electrochemical biosensors for the detection of SARS-CoV-2 pathogen and protein biomarkers

Yintang Zhang; Fang Chen; Hao Xie; Binbin Zhou

doi:10.20964/2022.05.13

Electrochemical biosensors for the detection of SARS-CoV-2 pathogen and protein biomarkers

Int J Electrochem Sci. 2022 May;17(5):220541. doi: 10.20964/2022.05.13. Epub 2023 Jun 17.

Authors

Yintang Zhang^{1

2}, Fang Chen^{1

2}, Hao Xie³, Binbin Zhou³

Affiliations

¹ Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, Henan 476000, P. R. China.
² Henan Joint International Research Laboratory of Chemo/Biosensing and Early Diagnosis of Major Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, Henan 476000, P. R. China.
³ College of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan 414006, P. R. China.

Abstract

Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV CoV-2) pathogen and protein biomarkers can improve the diagnosis accuracy for Coronavirus disease 2019 (COVID-19). Electrochemical biosensors have attracted extensive attention in the scientific community because of their simple design, fast response, good portability, high sensitivity and high selectivity. In this review, we summarized the progress in the electrochemical detection of COVID-19 pathogen and SARS-CoV-2 biomarkers, including SARS-CoV-2 spike protein and nucleocapsid protein and their antibodies.

Keywords: Coronavirus disease 2019; SARS-CoV-2 nucleocapsid protein; SARS-CoV-2 spike protein; antibody; electrochemical biosensors.

Publication types

Review