Functionalized Magnetic Nanoparticles for NIR-Induced Photothermal Therapy of Potential Application in Cervical Cancer

Linxue Zhang; Gulinigaer Alimu; Zhong Du; Ting Yan; Hui Li; Rong Ma; Zhongwen Lan; Zhong Yu; Nuernisha Alifu; Ke Sun

doi:10.1021/acsomega.3c01374

Functionalized Magnetic Nanoparticles for NIR-Induced Photothermal Therapy of Potential Application in Cervical Cancer

ACS Omega. 2023 Jun 8;8(24):21793-21801. doi: 10.1021/acsomega.3c01374. eCollection 2023 Jun 20.

Authors

Linxue Zhang^{1

2}, Gulinigaer Alimu¹, Zhong Du³, Ting Yan¹, Hui Li¹, Rong Ma³, Zhongwen Lan², Zhong Yu², Nuernisha Alifu¹, Ke Sun²

Affiliations

¹ State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia/School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830054, China.
² School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, China.
³ State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia/Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.

Abstract

Photothermal therapy (PTT) holds great promise for cancer treatment with its effective ablation of solid tumors. As the essential core point, photothermal agents (PTAs) with excellent photothermal properties and good biocompatibility could help to fulfill highly efficient PTT. Herein, a novel type of nanoplatform Fe₃O₄@PDA/ICG (FPI) nanoparticle (NP) was designed and synthesized, which was composed of magnetic Fe₃O₄ and near-infrared excitable indocyanine green via encapsulation of polydopamine. The FPI NPs showed spherical structures in shape with uniform distribution and good chemical stability. Under 793 nm laser irradiation, FPI NPs could generate hyperthermia of 54.1 °C and photothermal conversion efficiency of 35.21%. The low cytotoxicity of FPI NPs was further evaluated and confirmed on HeLa cells with a high survival rate (90%). Moreover, under laser irradiation (793 nm), FPI NPs showed effective photothermal therapeutic characteristics for HeLa cells. Therefore, FPI NPs, as one of the promising PTAs, have great potential in the field of PTT for tumor treatment.