Reduced regional cerebral oxygen saturation increases risk for emergence delirium in pediatric patients

Lijing Li; Zhengzheng Gao; Jianmin Zhang; Fuzhou Zhang; Fang Wang; Xiaoxue Wang; Gan Li

doi:10.3389/fped.2023.1117455

Reduced regional cerebral oxygen saturation increases risk for emergence delirium in pediatric patients

Front Pediatr. 2023 Jun 8:11:1117455. doi: 10.3389/fped.2023.1117455. eCollection 2023.

Authors

Lijing Li¹, Zhengzheng Gao¹, Jianmin Zhang¹, Fuzhou Zhang¹, Fang Wang¹, Xiaoxue Wang¹, Gan Li¹

Affiliation

¹ Department of Anesthesiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Abstract

Objectives: To assess whether decreased regional cerebral oxygen saturation (rScO₂) is associated with the emergence delirium (ED) following general anesthesia in the pediatric population.

Methods: A retrospective observational cohort study was conducted on 113 children (ASA I-III) aged 2-14 years who underwent selective surgery under general anesthesia between 2022-01 and 2022-04. Intraoperatively, the rScO₂ was monitored using a cerebral oximeter. The Pediatric Anesthesia Emergence Delirium (PAED) score was used to evaluate the patients for ED.

Results: The incidence of ED was 31%. Low rScO₂ was reported in 41.6% of patients, who had a higher incidence of ED (P < 0.001) than those who did not experience desaturation. Logistic regression analysis revealed that decreased rScO₂ was significantly associated with incident ED events [odds ratio (OR), 10.77; 95% confidence interval, 3.31-35.05]. Children under 3 years of age had a higher incidence of ED after rScO₂ desaturation during anesthesia compared to older children (OR, 14.17 vs. 4.64).

Conclusion: Intraoperative rScO₂ desaturation significantly increased the incidence of ED following general anesthesia. Monitoring should be enhanced to improve the oxygen balance in vital organs to improve the quality and safety of anesthesia.

Keywords: children; desaturation; emergence delirium; general anesthesia; regional cerebral oxygen saturation.