Current analysis of hypoxic-ischemic encephalopathy research issues and future treatment modalities

Hong-Qing She; Yi-Fei Sun; Li Chen; Qiu-Xia Xiao; Bo-Yan Luo; Hong-Su Zhou; Di Zhou; Quan-Yuan Chang; Liu-Lin Xiong

doi:10.3389/fnins.2023.1136500

Current analysis of hypoxic-ischemic encephalopathy research issues and future treatment modalities

Front Neurosci. 2023 Jun 9:17:1136500. doi: 10.3389/fnins.2023.1136500. eCollection 2023.

Authors

Hong-Qing She^{1

2

3}, Yi-Fei Sun⁴, Li Chen⁴, Qiu-Xia Xiao⁴, Bo-Yan Luo³, Hong-Su Zhou^{1

2

3}, Di Zhou¹, Quan-Yuan Chang⁵, Liu-Lin Xiong^{1

2

3}

Affiliations

¹ Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
² Translational Neurology Laboratory, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
³ WANG TINGHUA Translation Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
⁴ Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, China.
⁵ Department of Anesthesiology, Southwest Medical University, Luzhou, China.

Abstract

Hypoxic-ischemic encephalopathy (HIE) is the leading cause of long-term neurological disability in neonates and adults. Through bibliometric analysis, we analyzed the current research on HIE in various countries, institutions, and authors. At the same time, we extensively summarized the animal HIE models and modeling methods. There are various opinions on the neuroprotective treatment of HIE, and the main therapy in clinical is therapeutic hypothermia, although its efficacy remains to be investigated. Therefore, in this study, we discussed the progress of neural circuits, injured brain tissue, and neural circuits-related technologies, providing new ideas for the treatment and prognosis management of HIE with the combination of neuroendocrine and neuroprotection.

Keywords: bibliometric analysis; hypothermia; hypoxic-ischemic encephalopathy (HIE); monkey; neural circuits.

Publication types

Review