Progress on the hippocampal circuits and functions based on sharp wave ripples

Abstract

Sharp wave ripples (SWRs) are high-frequency synchronization events generated by hippocampal neuronal circuits during various forms of learning and reactivated during memory consolidation and recall. There is mounting evidence that SWRs are essential for storing spatial and social memories in rodents and short-term episodic memories in humans. Sharp wave ripples originate mainly from the hippocampal CA3 and subiculum, and can be transmitted to modulate neuronal activity in cortical and subcortical regions for long-term memory consolidation and behavioral guidance. Different hippocampal subregions have distinct functions in learning and memory. For instance, the dorsal CA1 is critical for spatial navigation, episodic memory, and learning, while the ventral CA1 and dorsal CA2 may work cooperatively to store and consolidate social memories. Here, we summarize recent studies demonstrating that SWRs are essential for the consolidation of spatial, episodic, and social memories in various hippocampal-cortical pathways, and review evidence that SWR dysregulation contributes to cognitive impairments in neurodegenerative and neurodevelopmental diseases.

Keywords: Hippocampus; Interneurons; Memory; Sharp wave ripples; Subiculum.