Association between SUMF1 polymorphisms and COVID-19 severity

BMC Genom Data. 2023 Jun 21;24(1):34. doi: 10.1186/s12863-023-01133-6.

Abstract

Background: Evidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor 1 (SUMF1) gene is involved in alveolar damage and systemic inflammatory response. Therefore, we speculate that it may play a key role in COVID-19.

Results: We found that rs794185 was significantly associated with COVID-19 severity in Chinese population, under the additive model after adjusting for gender and age (for C allele = 0.62, 95% CI = 0.44-0.88, P = 0.0073, logistic regression). And this association was consistent with this in European population Genetics Of Mortality In Critical Care (GenOMICC: OR for C allele = 0.94, 95% CI = 0.90-0.98, P = 0.0037). Additionally, we also revealed a remarkable association between rs794185 and the prothrombin activity (PTA) in subjects (P = 0.015, Generalized Linear Model).

Conclusions: In conclusion, our study for the first time identified that rs794185 in SUMF1 gene was associated with the severity of COVID-19.

Keywords: COVID-19; Multiple sclerosis; SUMF1; rs794185.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19* / genetics
  • Humans
  • Oxidoreductases Acting on Sulfur Group Donors / genetics
  • Polymorphism, Genetic
  • Sulfatases* / genetics

Substances

  • Sulfatases
  • SUMF1 protein, human
  • Oxidoreductases Acting on Sulfur Group Donors