Derivation of induced pluripotent stem cell SJTUi003-A from a 69-year-old Chinese Han Sporadic Alzheimer's disease patient with APOEε3/ε4 genetic background

Hui Li; Bei Zhang; Zhiqiang Shi; Hui Wu; Shuya Mei; Tianyi Ai; An Shi; Lihui Wang; Mingli Zhu; Jiajia Tang

doi:10.1016/j.scr.2023.103142

Derivation of induced pluripotent stem cell SJTUi003-A from a 69-year-old Chinese Han Sporadic Alzheimer's disease patient with APOEε3/ε4 genetic background

Stem Cell Res. 2023 Sep:71:103142. doi: 10.1016/j.scr.2023.103142. Epub 2023 Jun 14.

Authors

Hui Li¹, Bei Zhang², Zhiqiang Shi¹, Hui Wu¹, Shuya Mei¹, Tianyi Ai¹, An Shi¹, Lihui Wang¹, Mingli Zhu³, Jiajia Tang⁴

Affiliations

¹ Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China.
² Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address: zhangbei0227@163.com.
³ Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China. Electronic address: millionzhu525@126.com.
⁴ Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China. Electronic address: czzhuxi@163.com.

PMID: 37343430
DOI: 10.1016/j.scr.2023.103142

Abstract

Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disease. In this study, we generated an induced pluripotent stem cell (iPSC) line from the dermal fibroblasts of a 69-year-old female patient carrying APOEε3/ε4 allele and diagnosed with sporadic AD. The iPSC line will be a useful tool for investigating the pathogenesis mechanisms and for drug tests in AD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alzheimer Disease* / pathology
Cell Line*
East Asian People
Female
Humans
Induced Pluripotent Stem Cells* / metabolism
Neurodegenerative Diseases* / metabolism