Role of G-protein coupled receptors in cardiovascular diseases

Yuanqiang Li; Boyu Li; Wei-Dong Chen; Yan-Dong Wang

doi:10.3389/fcvm.2023.1130312

Role of G-protein coupled receptors in cardiovascular diseases

Front Cardiovasc Med. 2023 Jun 5:10:1130312. doi: 10.3389/fcvm.2023.1130312. eCollection 2023.

Authors

Yuanqiang Li¹, Boyu Li², Wei-Dong Chen^{3

4}, Yan-Dong Wang¹

Affiliations

¹ State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
² Department of Gastroenterology and Hematology, The People's Hospital of Hebi, Henan, China.
³ Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, School of Basic Medical Science, Inner Mongolia Medical University, Hohhot, China.
⁴ Key Laboratory of Receptors-Mediated Gene Regulation, School of Medicine, The People's Hospital of Hebi, Henan University, Kaifeng, China.

Abstract

Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an essential regulating cellular physiology and pathology. Some GPCR antagonists, such as β-blockers, are standard therapy for the treatment of CVDs. In addition, nearly one-third of the drugs used to treat CVDs target GPCRs. All the evidence demonstrates the crucial role of GPCRs in CVDs. Over the past decades, studies on the structure and function of GPCRs have identified many targets for the treatment of CVDs. In this review, we summarize and discuss the role of GPCRs in the function of the cardiovascular system from both vascular and heart perspectives, then analyze the complex ways in which multiple GPCRs exert regulatory functions in vascular and heart diseases. We hope to provide new ideas for the treatment of CVDs and the development of novel drugs.

Keywords: G-protein-coupled receptors; cardiovascular diseases; heart function; ischemia-reperfusion; vascular tone.

Publication types

Review

Grants and funding

This work was funded by the National Natural Science Foundation of China (grant no. 81970551) and National Key R&D Program of China (2021YFC2103900) to Y-DW, the National Natural Science Foundation of China (grant no. 81970726), Henan Provincial Natural Science Foundation (grant no.182300410323), Program for Science & Technology Innovation Talents in Universities of Henan Province (HASTIT, grant no. 13HASTIT024), Plan for Scientific Innovation Talent of Henan Province, and National College Student Innovation and Entrepreneurship Training Program (grant no. 202010475032) to W-DC.