Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts

Eleonora Timperi; Emanuela Romano

doi:10.3389/fimmu.2023.1194642

Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts

Front Immunol. 2023 Jun 5:14:1194642. doi: 10.3389/fimmu.2023.1194642. eCollection 2023.

Authors

Eleonora Timperi¹, Emanuela Romano^{1

2}

Affiliations

¹ Department of Immunology, INSERM U932, Université Paris Sciences et Lettres (PSL) Research University, Institut Curie, Paris, France.
² Department of Medical Oncology, Center for Cancer Immunotherapy, Institut Curie, Paris, France.

Abstract

The tumor associated macrophages (TAM) represent one of most abundant subpopulations across several solid cancers and their number/frequency is associated with a poor clinical outcome. It has been clearly demonstrated that stromal cells, such as the cancer associated fibroblasts (CAFs), may orchestrate TAM recruitment, survival and reprogramming. Today, single cell-RNA sequencing (sc-RNA seq) technologies allowed a more granular knowledge about TAMs and CAFs phenotypical and functional programs. In this mini-review we discuss the recent discoveries in the sc-RNA seq field focusing on TAM and CAF identity and their crosstalk in the tumor microenvironment (TME) of solid cancers.

Keywords: cancer associated fibroblasts (CAF); monocytes; single cell RNA analysis; solid tumors; tumor associated macrophages (TAM).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cancer-Associated Fibroblasts* / pathology
Neoplasms* / pathology
Stromal Cells
Tumor-Associated Macrophages

Grants and funding

This work was supported by the following grants to ER: Foundation ARC (grant no. AAP SIGN’IT 2019), Fonds Amgen France pour la Science et l’Humain; CIC IGR-Curie 1428; ANR-10-IDEX-0001-02 PSL; and ANR- 11-LABX-0043. ET was supported by a postdoctoral fellowship abroad from the AIRC (2018/2020-number: 20934).