Genetic Variants of CYP4F2 Associated with Ischemic Stroke Susceptibility in the Han Population from Southern China

Kang Huang; Tianyi Ma; Qiang Li; Yilei Zhou; Ting Qin; Zanrui Zhong; Shilin Tang; Wei Zhang; Jianghua Zhong; Shijuan Lu

doi:10.2147/PGPM.S413632

Genetic Variants of CYP4F2 Associated with Ischemic Stroke Susceptibility in the Han Population from Southern China

Pharmgenomics Pers Med. 2023 Jun 15:16:599-607. doi: 10.2147/PGPM.S413632. eCollection 2023.

Authors

Kang Huang^#¹, Tianyi Ma^#¹, Qiang Li¹, Yilei Zhou², Ting Qin¹, Zanrui Zhong¹, Shilin Tang¹, Wei Zhang¹, Jianghua Zhong¹, Shijuan Lu¹

Affiliations

¹ Department of Cardiovascular Medicine, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, People's Republic of China.
² Medical College, Jingchu University of Technology, Jingmen, Hubei, People's Republic of China.

^# Contributed equally.

Abstract

Background: The pathophysiological mechanism of ischemic stroke is complex. Traditional risk factors cannot fully or only partially explain the occurrence and development of IS. Genetic factors are getting more and more attention. Our study aimed to explore the association between CYP4F2 gene polymorphism and susceptibility to IS.

Methods: A total of 1322 volunteers were enrolled to perform an association analysis through SNPStats online software. Using FPRP (false-positive report probability) to detect whether the result is a noteworthy finding. The interaction of SNP-SNP in IS risk was assessed by multi-factor dimensionality reduction. Statistical analysis of this study was mainly completed by SPSS 22.0 software.

Results: Mutant allele "A" (OR = 1.24) and genotype "AA" (OR = 1.49) or "GA" (OR = 1.26) of CYP4F2-rs2108622 are risk genetic factors for IS. Rs2108622 is significantly associated with an increased risk of IS among subjects who are females, aging >60 years old, with BMI ≥24 kg/m², and smoking or drinking volunteers. CYP4F2-rs3093106 and -rs3093105 are associated with susceptibility to IS among smoking, drinking subjects, or IS patients complicated with hypertension.

Conclusion: CYP4F2-rs2108622, -rs3093106, and -rs3093105 are associated with an increased risk of IS.

Keywords: CYP4F2; association analysis; genetic variants; ischemic stroke; susceptibility.

Grants and funding

This study was supported by the specific research fund of the Innovation Platform for Academicians of Hainan Province: Dynamic monitoring and genetic correlation of blood biochemical indexes related to cardiovascular and cerebrovascular diseases in “migratory bird population” in Hainan (No. YSPTZX202032).