Introduction: Previous studies have indicated that COVID-19 symptoms may persist for up to 12 months after recovery; however, data on this phenomenon are still limited.
Objectives: The aim of this study was to assess the prevalence, the most common symptoms, and the risk factors for development of post-COVID syndrome in hospitalized and nonhospitalized patients during a 12-month follow-up after recovery from COVID-19.
Patients and methods: This longitudinal study was based on medical data collected at follow-up visits at 3 and 12 months post-COVID-19. Sociodemographic data, chronic conditions, and the most common clinical symptoms were assessed. A total of 643 patients were enrolled in the final analysis.
Results: A majority of the study group were women (63.1%), and the median age of the entire group was 52 years (interquartile range [IQR] 43-63). After 12 months, a median of 65.7% (IQR, 62.1%-69.6%) of the patients declared the presence of at least 1 clinical symptom of post-COVID syndrome. The most common complaints were asthenia (median, 45.7% [IQR, 41.9%-49.6%]) and neurocognitive symptoms (median, 40% [IQR, 36%-40.1%]). In a multivariable analysis, female sex (odds ratio [OR] 1.49; P = 0.01) and severe COVID-19 course (OR, 3.05; P <0.001) were associated with persistence of clinical symptoms for up to 12 months after recovery.
Conclusions: After 12 months, persistent symptoms were declared by 65.7% of the patients. The most common symptoms 3 and 12 months after the infection were worse tolerance to exercise, fatigue, palpitations, and memory or concentration problems. Women are at a higher risk of experiencing persistent symptoms, and COVID-19 severity was a predictor of persistent post-COVID-19 symptoms.