Diverse aspidosperma-type alkaloids from the leaves of Tabernaemontana bovina with anti-hepatoma activity

Yang Yu; Jing Wu; Mei-Fen Bao; Johann Schinnerl; Xiang-Hai Cai

doi:10.1016/j.fitote.2023.105588

Diverse aspidosperma-type alkaloids from the leaves of Tabernaemontana bovina with anti-hepatoma activity

Fitoterapia. 2023 Sep:169:105588. doi: 10.1016/j.fitote.2023.105588. Epub 2023 Jun 17.

Authors

Yang Yu¹, Jing Wu¹, Mei-Fen Bao¹, Johann Schinnerl², Xiang-Hai Cai³

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
² Chemodiversity Research Group, Division of Systematic and Evolutionary Botany, University of Vienna, Rennweg 14, A-1030 Vienna, Austria.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: xhcai@mail.kib.ac.cn.

PMID: 37336417
DOI: 10.1016/j.fitote.2023.105588

Abstract

Seventeen undescribed Aspidosperma-type alkaloids (ASPs), along with nine known ones were isolated from the leaves of Tabernaemontana bovina. Taberbovermines A and B were assigned to tabersonine-type with a contracted A- and E-ring, respectively. Taberbovermine C was attributed to tabersonine without D ring. These structures of the ASPs were established on the basis of comprehensive spectroscopic data, electronic circular dichroism calculations and X-ray diffraction. The summaries of structure-activity relationship of tabersonine class were discussed based on hepatoma cells screening.

Keywords: Apocynaceae; Aspidosperma alkaloids; Hepatom; Structure-activity relationship; Taberbovermines; Tabernaemontana bovina.

MeSH terms

Alkaloids* / chemistry
Aspidosperma* / chemistry
Indole Alkaloids / chemistry
Molecular Structure
Plant Leaves / chemistry
Tabernaemontana* / chemistry

Substances

Alkaloids
Indole Alkaloids