Functional photoacoustic imaging: from nano- and micro- to macro-scale

Byullee Park; Donghyeon Oh; Jeesu Kim; Chulhong Kim

doi:10.1186/s40580-023-00377-3

Functional photoacoustic imaging: from nano- and micro- to macro-scale

Nano Converg. 2023 Jun 19;10(1):29. doi: 10.1186/s40580-023-00377-3.

Authors

Byullee Park^#^{1

2

3}, Donghyeon Oh^#¹, Jeesu Kim⁴, Chulhong Kim⁵

Affiliations

¹ Departments of Convergence IT Engineering, Mechanical Engineering, and Electrical Engineering, School of Interdisciplinary Bioscience and Bioengineering, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
² Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
³ Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
⁴ Departments of Cogno-Mechatronics Engineering and Optics and Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, 46241, Republic of Korea. jeesukim@pusan.ac.kr.
⁵ Departments of Convergence IT Engineering, Mechanical Engineering, and Electrical Engineering, School of Interdisciplinary Bioscience and Bioengineering, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea. chulhong@postech.edu.

^# Contributed equally.

Abstract

Functional photoacoustic imaging is a promising biological imaging technique that offers such unique benefits as scalable resolution and imaging depth, as well as the ability to provide functional information. At nanoscale, photoacoustic imaging has provided super-resolution images of the surface light absorption characteristics of materials and of single organelles in cells. At the microscopic and macroscopic scales. photoacoustic imaging techniques have precisely measured and quantified various physiological parameters, such as oxygen saturation, vessel morphology, blood flow, and the metabolic rate of oxygen, in both human and animal subjects. This comprehensive review provides an overview of functional photoacoustic imaging across multiple scales, from nano to macro, and highlights recent advances in technology developments and applications. Finally, the review surveys the future prospects of functional photoacoustic imaging in the biomedical field.

Keywords: Biomedical imaging; Functional photoacoustic imaging; Multiscale photoacoustic imaging; Photoacoustic imaging; Ultrasound imaging.

Publication types

Review

Abstract

Publication types

Grants and funding