Novelties in the pharmacological approaches for chronic heart failure: new drugs and cardiovascular targets

Michele Correale; Lucia Tricarico; Francesca Croella; Simona Alfieri; Francesco Fioretti; Natale Daniele Brunetti; Riccardo M Inciardi; Savina Nodari

doi:10.3389/fcvm.2023.1157472

Novelties in the pharmacological approaches for chronic heart failure: new drugs and cardiovascular targets

Front Cardiovasc Med. 2023 Jun 2:10:1157472. doi: 10.3389/fcvm.2023.1157472. eCollection 2023.

Authors

Michele Correale¹, Lucia Tricarico¹, Francesca Croella², Simona Alfieri², Francesco Fioretti³, Natale Daniele Brunetti², Riccardo M Inciardi³, Savina Nodari³

Affiliations

¹ Department of Cardiothoracic, Policlinico Riuniti University Hospital, Foggia, Italy.
² Department of Medical & Surgical Sciences, University of Foggia, Foggia, Italy.
³ Cardiology Section, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, ASST Spedali Civili Hospital and University of Brescia, Brescia, Italy.

Abstract

Despite recent advances in chronic heart failure (HF) management, the prognosis of HF patients is poor. This highlights the need for researching new drugs targeting, beyond neurohumoral and hemodynamic modulation approach, such as cardiomyocyte metabolism, myocardial interstitium, intracellular regulation and NO-sGC pathway. In this review we report main novelties on new possible pharmacological targets for HF therapy, mainly on new drugs acting on cardiac metabolism, GCs-cGMP pathway, mitochondrial function and intracellular calcium dysregulation.

Keywords: CGMP pathway; cardiac metabolism; heart failure; mitochondrial function; new drugs; therapy targets.

Publication types

Review