The pontine diffuse midline glioma, EGFR-subtype with ependymal features: Yet another face of diffuse midline glioma, H3K27-altered

Brain Pathol. 2024 Jan;34(1):e13181. doi: 10.1111/bpa.13181. Epub 2023 Jun 18.

Arnault Tauziède-Espariat^{1

2}, Alice Métais^{1

2}, Cassandra Mariet¹, David Castel³, Jacques Grill^{3

4}, Raphaël Saffroy⁵, Lauren Hasty¹, Volodia Dangouloff-Ros^{6

7}, Nathalie Boddaert^{6

7}, Sandro Benichi⁸, Fabrice Chrétien¹, Pascale Varlet^{1

2}

¹ Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, Paris, France.
² Inserm, UMR 1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France.
³ U981, Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
⁴ Department of Pediatric Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
⁵ Department of Biochemistry and Oncogenetic, Paul Brousse Hospital, APHP, Villejuif, France.
⁶ Pediatric Radiology Department, Hôpital Necker Enfants Malades, AP-HP, Paris, France.
⁷ UMR 1163, Institut Imagine and INSERM U1299, Université Paris Cité, Paris, France.
⁸ Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cite, Paris, France.

Abstract

Diffuse midline glioma with two components: classical glial and ependymal.

Keywords: EGFR; EZHIP; diffuse midline glioma; ependymoma.