Impact of pre-burn statin use on metabolic and cardiovascular disorders

Tsola A Efejuku; Grace Obanigba; Dominique Johnson; Ann Obi; Taylor Hallman; Juquan Song; Amina El Ayadi; Mukaila Raji; Steven E Wolf

doi:10.1016/j.amjsurg.2023.06.003

Impact of pre-burn statin use on metabolic and cardiovascular disorders

Am J Surg. 2023 Oct;226(4):485-491. doi: 10.1016/j.amjsurg.2023.06.003. Epub 2023 Jun 12.

Authors

Tsola A Efejuku¹, Grace Obanigba², Dominique Johnson³, Ann Obi⁴, Taylor Hallman⁵, Juquan Song⁶, Amina El Ayadi⁷, Mukaila Raji⁸, Steven E Wolf⁹

Affiliations

¹ School of Medicine, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: taefejuk@utmb.edu.
² School of Medicine, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: goobanig@utmb.edu.
³ School of Medicine, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: dobjohns@utmb.edu.
⁴ School of Medicine, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: anobi@utmb.edu.
⁵ School of Medicine, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: thgallma@utmb.edu.
⁶ Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: jusong@utmb.edu.
⁷ Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: amelayad@utmb.edu.
⁸ Division of Geriatric & Palliative Medicine, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: muraji@utmb.edu.
⁹ Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: swolf@utmb.edu.

PMID: 37330384
DOI: 10.1016/j.amjsurg.2023.06.003

Abstract

Introduction: Statins are among the most widely prescribed medications with proven effectiveness in patients with hyperlipidemia and atherosclerotic cardiovascular diseases. We investigated the relationship between statin use, metabolic and cardiovascular outcomes after burn.

Methods: We utilized data from the TriNetX electronic health database. Burn patients with prior statin use were compared to patients without prior use and analyzed the occurrence of metabolic and cardiovascular disorders.

Results: Prior statin use burn patients were 1.33 times as likely to develop hyperglycemia, 1.20 times for cardiac arrhythmia, 1.70 times for coronary artery disease (CAD), 1.10 times for sepsis, and 0.80 times for death. High percent TBSA burn, male sex, and lipophilic statin use were associated with higher odds of outcome development.

Conclusion: Prior statin use in severely burned patients is associated with an increased risk of developing hyperglycemia, arrhythmias, and CAD, with higher odds in males, higher TBSA burn, and lipophilic statin users.

Keywords: Burn; Cardiovascular outcomes; Metabolic disorders; Outcomes; Patients database; Statin.

MeSH terms

Burns* / complications
Burns* / drug therapy
Cardiovascular Diseases* / prevention & control
Coronary Artery Disease* / chemically induced
Coronary Artery Disease* / drug therapy
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors* / therapeutic use
Hyperglycemia* / chemically induced
Male
Risk Factors

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors