The versatile roles of lumican in eye diseases: A review

Mei-Chi Tsui; Hsin-Yu Liu; Hsiao-Sang Chu; Wei-Li Chen; Fung-Rong Hu; Winston W-Y Kao; I-Jong Wang

doi:10.1016/j.jtos.2023.06.012

The versatile roles of lumican in eye diseases: A review

Ocul Surf. 2023 Jul:29:388-397. doi: 10.1016/j.jtos.2023.06.012. Epub 2023 Jun 14.

Authors

Mei-Chi Tsui¹, Hsin-Yu Liu², Hsiao-Sang Chu², Wei-Li Chen³, Fung-Rong Hu⁴, Winston W-Y Kao⁵, I-Jong Wang⁶

Affiliations

¹ Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; Department of Ophthalmology, An Nan Hospital, China Medical University, Tainan, Taiwan.
² Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; Advanced Ocular Surface and Corneal Nerve Regeneration Center, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
³ Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; Advanced Ocular Surface and Corneal Nerve Regeneration Center, National Taiwan University Hospital, Taipei, Taiwan; Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan.
⁴ Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan.
⁵ Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
⁶ Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: ijong@ms8.hinet.net.

PMID: 37327869
DOI: 10.1016/j.jtos.2023.06.012

Abstract

Lumican is a keratan sulfate proteoglycan that belongs to the small leucine-rich proteoglycan family. Research has lifted the veil on the versatile roles of lumican in the pathogenesis of eye diseases. Lumican has pivotal roles in the maintenance of physiological tissue homogenesis and is often upregulated in pathological conditions, e.g., fibrosis, scar tissue formation in injured tissues, persistent inflammatory responses and immune anomaly, etc. Herein, we will review literature regarding the role of lumican in pathogenesis of inherited congenital and acquired eye diseases, e.g., cornea dystrophy, cataract, glaucoma and chorioretinal diseases, etc.

Keywords: Corneal inflammation; Corneal transparency; Corneal wound healing; Lumican; Myopia; Scleral integrity; Small leucine-rich proteoglycans (SLRP).

Publication types

Review

MeSH terms

Chondroitin Sulfate Proteoglycans / physiology
Cornea / pathology
Eye Diseases* / metabolism
Eye Diseases* / pathology
Humans
Keratan Sulfate / physiology
Lumican*
Proteoglycans / physiology

Substances

Chondroitin Sulfate Proteoglycans
Keratan Sulfate
Lumican
Proteoglycans