Noncoding translation: Quality control in the BAG

Jessica J Mohsen; Sarah A Slavoff

doi:10.1016/j.molcel.2023.05.033

Noncoding translation: Quality control in the BAG

Mol Cell. 2023 Jun 15;83(12):1967-1969. doi: 10.1016/j.molcel.2023.05.033.

Authors

Jessica J Mohsen¹, Sarah A Slavoff²

Affiliations

¹ Department of Chemistry, Yale University, New Haven, CT, USA; Institute for Biomolecular Design and Discovery, Yale University, West Haven, CT, USA.
² Department of Chemistry, Yale University, New Haven, CT, USA; Institute for Biomolecular Design and Discovery, Yale University, West Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. Electronic address: sarah.slavoff@yale.edu.

PMID: 37327774
DOI: 10.1016/j.molcel.2023.05.033

Abstract

Translation of noncoding regions is ubiquitous and upregulated in disease. Kesner et al.¹ elucidate the mechanism by which the BAG6 complex exerts quality control over noncoding translation while targeting stable, noncanonical polypeptides to cellular membranes.

MeSH terms

Molecular Chaperones*
Peptides*
Quality Control

Substances

Molecular Chaperones
Peptides