miRNAs orchestration of cardiovascular diseases - Particular emphasis on diagnosis, and progression

Elsayed G E Elsakka; Ahmed I Abulsoud; Hesham A El-Mahdy; Ahmed Ismail; Mohammed S Elballal; Sherif S Abdel Mageed; Emad Gamil Khidr; Osama A Mohammed; Omnia M Sarhan; Samy Y Elkhawaga; Ahmed A El-Husseiny; Nourhan M Abdelmaksoud; Aya A El-Demerdash; Reem K Shahin; Heba M Midan; Mahmoud A Elrebehy; Ayman A Doghish; Ahmed S Doghish

doi:10.1016/j.prp.2023.154613

miRNAs orchestration of cardiovascular diseases - Particular emphasis on diagnosis, and progression

Pathol Res Pract. 2023 Aug:248:154613. doi: 10.1016/j.prp.2023.154613. Epub 2023 Jun 12.

Authors

Elsayed G E Elsakka¹, Ahmed I Abulsoud², Hesham A El-Mahdy³, Ahmed Ismail¹, Mohammed S Elballal⁴, Sherif S Abdel Mageed⁵, Emad Gamil Khidr¹, Osama A Mohammed⁶, Omnia M Sarhan⁷, Samy Y Elkhawaga¹, Ahmed A El-Husseiny⁸, Nourhan M Abdelmaksoud⁹, Aya A El-Demerdash⁵, Reem K Shahin⁴, Heba M Midan⁴, Mahmoud A Elrebehy⁴, Ayman A Doghish¹⁰, Ahmed S Doghish¹¹

Affiliations

¹ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt.
² Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt; Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
³ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt. Electronic address: heshamabbas@azhar.edu.eg.
⁴ Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
⁵ Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
⁶ Department of Clinical Pharmacology, Faculty of Medicine, Bisha University, Bisha 61922, Saudi Arabia; Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
⁷ Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
⁸ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829 Cairo, Egypt.
⁹ Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
¹⁰ Department of Cardiovascular & Thoracic Surgery, Ain-Shams University Hospital, Faculty of Medicine, Cairo, Egypt.
¹¹ Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt. Electronic address: ahmed_doghish@azhar.edu.eg.

PMID: 37327567
DOI: 10.1016/j.prp.2023.154613

Abstract

MicroRNAs (miRNAs; miRs) are small non-coding ribonucleic acids sequences vital in regulating gene expression. They are significant in many biological and pathological processes and are even detectable in various body fluids such as serum, plasma, and urine. Research has demonstrated that the irregularity of miRNA in multiplying cardiac cells is linked to developmental deformities in the heart's structure. It has also shown that miRNAs are crucial in diagnosing and progressing several cardiovascular diseases (CVDs). The review covers the function of miRNAs in the pathophysiology of CVD. Additionally, the review provides an overview of the potential role of miRNAs as disease-specific diagnostic and prognostic biomarkers for human CVD, as well as their biological implications in CVD.

Keywords: Cardiovascular diseases; Diagnosis; Epigenetic regulation; MiRNA; Prognosis; Transcriptional regulation.

Publication types

Review