Strategies for in situ tissue engineering of vascularized bone regeneration (Review)

Yijun He; Lin Liang; Cheng Luo; Zhi-Yong Zhang; Jiongfeng Huang

doi:10.3892/br.2023.1625

Strategies for in situ tissue engineering of vascularized bone regeneration (Review)

Biomed Rep. 2023 May 22;18(6):42. doi: 10.3892/br.2023.1625. eCollection 2023 Jun.

Authors

Yijun He^{1

2}, Lin Liang¹, Cheng Luo¹, Zhi-Yong Zhang², Jiongfeng Huang¹

Affiliations

¹ Department of Osteoarthropathy and Sports Medicine, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong 511400, P.R. China.
² Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.

Abstract

Numerous physiological processes occur following bone fracture, including inflammatory cell recruitment, vascularization, and callus formation and remodeling. In particular circumstances, such as critical bone defects or osteonecrosis, the regenerative microenvironment is compromised, rendering endogenous stem/progenitor cells incapable of fully manifesting their reparative potential. Consequently, external interventions, such as grafting or augmentation, are frequently necessary. In situ bone tissue engineering (iBTE) employs cell-free scaffolds that possess microenvironmental cues, which, upon implantation, redirect the behavior of endogenous stem/progenitor cells towards a pro-regenerative inflammatory response and reestablish angiogenesis-osteogenesis coupling. This process ultimately results in vascularized bone regeneration (VBR). In this context, a comprehensive review of the current techniques and modalities in VBR-targeted iBTE technology is provided.

Keywords: cell-free scaffolds; in situ bone tissue engineering; microenvironment; vascularized bone regeneration.

Publication types

Review

Grants and funding

Funding: This work was supported by the National Natural Science Foundation of China (grant no. 82072415), Panyu Key Medical and Health Projects of Science and Technology Planning (grant no. 2022-Z04-101), Science and Technology Project of Foshan City (grant no. 1920001000025), Project of The State Key Laboratory of Respiratory Disease (grant no. SKLRD-Z-202105), Science Technology Project of Guangzhou City (grant no. 2019ZD15) and the Fundamental and Applied Basic Research Fund of Guangdong Province Regional Joint Fund Project (Youth Fund Project; grant no. 2020A1515111046).