Riboswitches, from cognition to transformation

Jingdong Xu; Junyuan Hou; Mengnan Ding; Zhiwen Wang; Tao Chen

doi:10.1016/j.synbio.2023.05.008

Riboswitches, from cognition to transformation

Synth Syst Biotechnol. 2023 Jun 3;8(3):357-370. doi: 10.1016/j.synbio.2023.05.008. eCollection 2023 Sep.

Authors

Jingdong Xu^{1

2

3}, Junyuan Hou^{1

2

3}, Mengnan Ding^{1

2

3}, Zhiwen Wang^{1

2

3}, Tao Chen^{1

2

3}

Affiliations

¹ School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, China.
² Frontier Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, 300350, China.
³ Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300350, China.

Abstract

Riboswitches are functional RNA elements that regulate gene expression by directly detecting metabolites. Twenty years have passed since it was first discovered, researches on riboswitches are becoming increasingly standardized and refined, which could significantly promote people's cognition of RNA function as well. Here, we focus on some representative orphan riboswitches, enumerate the structural and functional transformation and artificial design of riboswitches including the coupling with ribozymes, hoping to attain a comprehensive understanding of riboswitch research.

Keywords: Applications; Aptazymes; Gene regulatory elements; Ligand diversity; Riboswitches; Structural transformation.

Publication types

Review