Polysaccharides in contact lenses: From additives to bulk materials

Abstract

As the number of applications has increased, so has the demand for contact lenses comfort. Adding polysaccharides to lenses is a popular way to enhance comfort for wearers. However, this may also compromise some lens properties. It is still unclear how to balance the variation of individual lens parameters in the design of contact lenses containing polysaccharides. This review provides a comprehensive overview of how polysaccharide addition impacts lens wear parameters, such as water content, oxygen permeability, surface wettability, protein deposition, and light transmittance. It also examines how various factors, such as polysaccharide type, molecular weight, amount, and mode of incorporation into lenses modulate these effects. Polysaccharide addition can improve some wear parameters while reducing others depending on the specific conditions. The optimal method, type, and amount of added polysaccharides depend on the trade-off between various lens parameters and wear requirements. Simultaneously, polysaccharide-based contact lenses may be a promising option for biodegradable contact lenses as concerns regarding environmental risks associated with contact lens degradation continue to increase. It is hoped that this review will shed light on the rational use of polysaccharides in contact lenses to make personalized lenses more accessible.

Keywords: 2-Hydroxyethyl methacrylate (PubChem CID: 13360); Chitosan; Chitosan (PubChem CID: 71853); Contact lenses; Heparin (PubChem CID: 772); Hyaluronic acid; Hyaluronic acid (PubChem CID: 24759); Hydroxypropyl methylcellulose; Hydroxypropyl methylcellulose (PubChem CID: 57503849); Methacrylic acid (PubChem CID: 4093); Methacryloxypropyltris(trimethylsiloxy)silane (PubChem CID: 123371); N,N-dimethylacrylamide (PubChem CID: 17587); N-vinylpyrrolidone (PubChem CID: 6917); Sodium alginate (PubChem CID: 133126842); Wear comfort.