Skeletal muscle fibre morphology in childhood-insights into myopenia in pediatric liver disease

Amber Hager; Vera Mazurak; Michelle Noga; Susan M Gilmour; Diana R Mager

doi:10.1139/apnm-2023-0033

Skeletal muscle fibre morphology in childhood-insights into myopenia in pediatric liver disease

Appl Physiol Nutr Metab. 2023 Oct 1;48(10):730-750. doi: 10.1139/apnm-2023-0033. Epub 2023 Jun 15.

Authors

Amber Hager¹, Vera Mazurak¹, Michelle Noga^{2

3}, Susan M Gilmour^{2

4}, Diana R Mager^{1

2}

Affiliations

¹ Department of Agricultural, Food & Nutritional Sciences, University of Alberta, Edmonton, AB, Canada.
² Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
³ Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada.
⁴ Division of Pediatric Gastroenterology & Nutrition/Transplant Services, The Stollery Children's Hospital, Alberta Health Services, Edmonton, AB, Canada.

PMID: 37319441
DOI: 10.1139/apnm-2023-0033

Abstract

Skeletal muscle morphology in healthy children changes with age. Liver disease may preferentially affect type II fibres in adults with end-stage liver disease (ESLD). More research is needed on the effects of ESLD on muscle morphology in children.

Keywords: liver disease; muscle morphology; myopenia; pediatrics; transplantation.

Publication types

Review

MeSH terms

Adult
Child
End Stage Liver Disease*
Humans
Muscle Fibers, Skeletal*
Muscle, Skeletal
Muscular Atrophy