Tandem Ene/[4 + 2] Cycloaddition Reaction for the Synthesis of 9-Benzylphenanthrenes from Arynes and α-(Bromomethyl)styrenes

J Org Chem. 2023 Jul 7;88(13):8034-8041. doi: 10.1021/acs.joc.3c00051. Epub 2023 Jun 15.

Abstract

A tandem reaction for the synthesis of phenanthrenes from arynes and α-(bromomethyl)styrenes is reported. The transformation proceeds via an ene reaction of α-(bromomethyl)styrenes with arynes, followed by a [4 + 2] cycloaddition reaction. The reaction generates 9-benzylphenanthrene derivatives in moderate to excellent yields.

MeSH terms

  • Cyclization
  • Cycloaddition Reaction
  • Phenanthrenes*
  • Styrenes*

Substances

  • Styrenes
  • Phenanthrenes