Introduction: Objective • This study aimed to investigate the clinical value of combining platelet-rich fibrin (PRF) with nano silver (AgNP) dressing in the treatment of chronic refractory wounds.
Introduction: Methods • A total of 120 patients with chronic refractory wounds were selected from our hospital between January 2020 and January 2022. The patients were randomly divided into the control group and the study group, with 60 cases in each group. The control group received basic treatment combined with AgNP dressing, while the study group received PRF combined with AgNP dressing. A comparison was made between the two groups in terms of wound healing time, hS-CRP levels, VISUAL analogue scale (VAS) scores, procalcitonin (PCT) levels, clinical efficacy, and complications.
Introduction: Results • Before treatment, there were no significant differences in hS-CRP, VAS, and PCT levels between the two groups (P > .05). However, after treatment, the study group showed significantly lower hS-CRP, VAS, and PCT levels compared to the control group (P < .05). The study group also exhibited a shorter wound healing time, a higher rate of excellent and good curative effect (95.00% vs 81.67%) compared to the control group (χ2 = 5.175, P < .05), and a lower incidence of wound complications (6.67% vs 21.67%) compared to the control group (χ2 = 4.386, P < .05).
Introduction: Conclusions • The combination of PRF and AgNP dressing can effectively alleviate pain and local inflammation in patients with chronic refractory wounds, improve the wound healing rate, shorten the healing time, and reduce the risk of complications such as infection spread.