Unravelling the genetic architecture of human complex traits through whole genome sequencing

Ozvan Bocher; Cristen J Willer; Eleftheria Zeggini

doi:10.1038/s41467-023-39259-x

Unravelling the genetic architecture of human complex traits through whole genome sequencing

Nat Commun. 2023 Jun 14;14(1):3520. doi: 10.1038/s41467-023-39259-x.

Authors

Ozvan Bocher¹, Cristen J Willer^{2

3

4}, Eleftheria Zeggini^{5

6}

Affiliations

¹ Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
² Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
³ Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
⁴ Department of Computational Medicine and Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.
⁵ Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany. eleftheria.zeggini@helmholtz-munich.de.
⁶ Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine, Ismaninger Str. 22, 81675, Munich, Germany. eleftheria.zeggini@helmholtz-munich.de.

Abstract

Whole genome sequencing has enabled new insights into the genetic architecture of complex traits, especially through access to low-frequency and rare variation. This Comment highlights the key contributions from this technology and discusses considerations for its use and future perspectives.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Multifactorial Inheritance*
Whole Genome Sequencing