Positive Progesterone Receptor Expression in Meningioma May Increase the Transverse Relaxation: First Prospective Clinical Trial Using Single-Shot Ultrafast T2 Mapping

Zongye Li; Xiao Wang; Hongyan Zhang; Yijie Yang; Yue Zhang; Yuchuan Zhuang; Qinqin Yang; Eryuan Gao; Yanan Ren; Yong Zhang; Shuhui Cai; Zhong Chen; Congbo Cai; Yanbo Dong; Jianfeng Bao; Jingliang Cheng

doi:10.1016/j.acra.2023.05.012

Positive Progesterone Receptor Expression in Meningioma May Increase the Transverse Relaxation: First Prospective Clinical Trial Using Single-Shot Ultrafast T₂ Mapping

Acad Radiol. 2024 Jan;31(1):187-198. doi: 10.1016/j.acra.2023.05.012. Epub 2023 Jun 12.

Authors

Zongye Li¹, Xiao Wang¹, Hongyan Zhang², Yijie Yang³, Yue Zhang¹, Yuchuan Zhuang⁴, Qinqin Yang³, Eryuan Gao¹, Yanan Ren¹, Yong Zhang¹, Shuhui Cai³, Zhong Chen³, Congbo Cai³, Yanbo Dong⁵, Jianfeng Bao¹, Jingliang Cheng⁶

Affiliations

¹ Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshe Dong Road, Zhengzhou 450000, China (Z.L., X.W., Y.Z., E.G., Y.R., Y.Z., J.B., J.C.).
² Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China (H.Z.).
³ Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen, China (Y.Y., Q.Y., S.C., Z.C., C.C.).
⁴ Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York (Y.Z.).
⁵ Institute of Psychology, Herzen State Pedagogical University of Russia, Saint Petersburg, Russia (Y.D.).
⁶ Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshe Dong Road, Zhengzhou 450000, China (Z.L., X.W., Y.Z., E.G., Y.R., Y.Z., J.B., J.C.). Electronic address: fccchengjl@zzu.edu.cn.

PMID: 37316368
DOI: 10.1016/j.acra.2023.05.012

Abstract

Rationale and objectives: This project aims to investigate the diagnostic performance of multiple overlapping-echo detachment imaging (MOLED) technique-derived transverse relaxation time (T₂) maps in predicting progesterone receptor (PR) and S100 expression in meningiomas.

Materials and methods: 63 meningioma patients were enrolled from October 2021 to August 2022, who underwent a complete routine magnetic resonance imaging and T₂ MOLED, which can characterize the whole brain transverse relaxation time within 32 seconds in a single scan. After the surgical resection of meningiomas, the expression levels of PR and S100 were determined by an experienced pathologist using immunohistochemistry techniques. Histogram analysis was performed in tumor parenchyma based on the parametric maps. Independent t test and Mann-Whitney U test were applied for the comparison of histogram parameters between different groups, with a significance level of P < .05. Logistic regression and receiver operating characteristic (ROC) analysis with 95% confidence interval were conducted for the diagnostic efficiency evaluation.

Results: PR-positive group had significantly elevated T₂ histogram parameters (P = .001-.049) compared to the PR-negative group. The multivariate logistic regression model with T₂ showed the highest area under the ROC curve (AUC) for predicting PR expression (AUC=0.818). Additionally, the multivariate model also had the best diagnostic performance for predicting meningioma S100 expression (AUC=0.768).

Conclusion: The MOLED technique-derived T₂ maps can distinguish PR and S100 status in meningiomas preoperatively.

Keywords: Histogram analysis; Meningioma; Multiple overlapping-echo detachment imaging; Progesterone receptor; S100; Single-shot T(2) mapping.

MeSH terms

Diffusion Magnetic Resonance Imaging / methods
Humans
Magnetic Resonance Imaging / methods
Meningeal Neoplasms* / diagnostic imaging
Meningeal Neoplasms* / pathology
Meningeal Neoplasms* / surgery
Meningioma* / diagnostic imaging
Meningioma* / pathology
Meningioma* / surgery
Prospective Studies
Receptors, Progesterone
Retrospective Studies

Substances

Receptors, Progesterone