Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases

Tong Zhao; Yuchen Zhu; Rui Zhao; Shiyi Xiong; Jing Sun; Juntao Zhang; Daidi Fan; Jianjun Deng; Haixia Yang

doi:10.1016/j.phrs.2023.106820

Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases

Pharmacol Res. 2023 Jul:193:106820. doi: 10.1016/j.phrs.2023.106820. Epub 2023 Jun 12.

Authors

Tong Zhao¹, Yuchen Zhu¹, Rui Zhao¹, Shiyi Xiong¹, Jing Sun¹, Juntao Zhang¹, Daidi Fan², Jianjun Deng³, Haixia Yang⁴

Affiliations

¹ College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
² Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Biotech & Biomed Research Institute, School of Chemical Engineering, Northwest University, Xi'an, China.
³ State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Biotech & Biomed Research Institute, School of Chemical Engineering, Northwest University, Xi'an, China. Electronic address: dengjianjun@nwu.edu.cn.
⁴ College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address: hyang@cau.edu.cn.

PMID: 37315822
DOI: 10.1016/j.phrs.2023.106820

Abstract

Nuciferine aporphine alkaloid mainly exists in Nelumbo nucifera Gaertn and is a beneficial to human health, such as anti-obesity, lowering blood lipid, prevention of diabetes and cancer, closely associated with inflammation. Importantly, nuciferine may contribute to its bioactivities by exerting intense anti-inflammatory activities in multiple models. However, no review has summarized the anti-inflammatory effect of nuciferine. This review critically summarized the information regarding the structure-activity relationships of dietary nuciferine. Moreover, biological activities and clinical application on inflammation-related diseases, such as obesity, diabetes, liver, cardiovascular diseases, and cancer, as well as their potential mechanisms, involving oxidative stress, metabolic signaling, and gut microbiota has been reviewed. The current work provides a better understanding of the anti-inflammation properties of nuciferine against multiple diseases, thereby improving the utilization and application of nuciferine-containing plants across functional food and medicine.

Keywords: Bioactivities; Inflammation; Mechanisms; Nuciferine; Structure-activity relationships.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents / therapeutic use
Aporphines* / pharmacology
Aporphines* / therapeutic use
Humans
Liver* / metabolism
Structure-Activity Relationship

Substances

nuciferine
Aporphines
Anti-Inflammatory Agents