Comparing chronic obstructive pulmonary disease and depressive disorder in terms of inflammation-related biomarkers

Elżbieta Małujło-Balcerska; Kasper Sipowicz; Tadeusz Pietras

doi:10.5114/aoms/161803

Comparing chronic obstructive pulmonary disease and depressive disorder in terms of inflammation-related biomarkers

Arch Med Sci. 2023 May 24;19(3):814-819. doi: 10.5114/aoms/161803. eCollection 2023.

Authors

Elżbieta Małujło-Balcerska¹, Kasper Sipowicz², Tadeusz Pietras^{3

4}

Affiliations

¹ Department of Pneumonology, Medical University of Lodz, Lodz, Poland.
² Department of Interdisciplinary Disability Studies, Maria Grzegorzewska University, Warsaw, Poland.
³ Second Department of Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland.
⁴ Department of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by the presence of depressive symptoms.

Methods: Cytokine and deiodinase iodothyronines (DIOs) levels were evaluated in COPD patients and patients diagnosed with depressive disorder and control individuals. using enzyme-linked immunosorbent assays.

Results: Interleukin 1β (IL-1β), and tumor necrosis factor-α (TNF-α) levels were higher in COPD and depression patients than in control individuals. DIO2 were significantly lower in COPD and recurrent depressive disorder (rDD) patients than in controls.

Conclusions: Changes in the levels of IL-1β, TNF-α and DIO2 in COPD patients may explain the presence of depression in COPD patients.

Keywords: chronic obstructive pulmonary disease; cytokines; deiodinase iodothyronine; depressive disorder.