Implications of LncRNAs and CircRNAs in psoriasis: a review

Rongcan Shi; Rui Ma; Xingyu Jiang; Xinyi Tang; Yu Gong; Zengyang Yu; Yuling Shi

doi:10.1080/15476286.2023.2223486

Implications of LncRNAs and CircRNAs in psoriasis: a review

RNA Biol. 2023 Jan;20(1):334-347. doi: 10.1080/15476286.2023.2223486.

Authors

Rongcan Shi^{1

2

3}, Rui Ma^{1

2

3}, Xingyu Jiang^{1

2

3}, Xinyi Tang^{2

3}, Yu Gong^{2

3}, Zengyang Yu^{2

3}, Yuling Shi^{1

2

3}

Affiliations

¹ Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
² Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
³ Institute of Psoriasis, Tongji University School of Medicine, Shanghai, China.

Abstract

Psoriasis is a chronic inflammatory skin disease characterized by skin infiltration of immune cells and abnormal epidermal thickening. The initial pathogenesis has not been fully elucidated. Non-coding RNAs (ncRNAs), which include long ncRNAs (lncRNAs) and circular RNAs (circRNAs), comprise the majority of genome transcripts and are important influencers of gene transcription and post-transcription modulations. Emerging roles of ncRNAs in psoriasis were identified recently. This review summarizes the existing studies of psoriasis-related lncRNAs and circRNAs. A considerable proportion of the studied lncRNAs and circRNAs regulate keratinocyte mobility, such as keratinocyte proliferation and differentiation. Some lncRNAs and circRNAs are tightly related to keratinocyte inflammation reactions. Other reports demonstrated that they are also implicated in modulating immune cell differentiation, proliferation, and activation. This review might illuminate future psoriasis research and highlight that lncRNAs and circRNAs might act as therapeutic targets.

Keywords: CircRNA; Immune cell; Keratinocyte; LncRNA; Psoriasis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Keratinocytes
Psoriasis* / genetics
RNA, Circular / genetics
RNA, Long Noncoding* / genetics
Skin

Substances

RNA, Long Noncoding
RNA, Circular

Grants and funding

National Natural Science Foundation of China (Nos. 81872522, 82073429, 81803120, 82103712), Innovation Program of Shanghai Municipal Education Commission (No. 2019-01-07-00-07-E00046), Clinical Research Plan of SHDC (Nos. SHDC2020CR1014B, SHDC12018×06), and the Program of Shanghai Academic Research Leader (No. 20×D1403300).