A Grim link: the association between subclinical atherosclerosis and epigenetic age

Nivedhitha Velayutham; Richard T Lee

doi:10.1093/eurheartj/ehad326

A Grim link: the association between subclinical atherosclerosis and epigenetic age

Eur Heart J. 2023 Aug 1;44(29):2710-2712. doi: 10.1093/eurheartj/ehad326.

Authors

Nivedhitha Velayutham¹, Richard T Lee^{1

2}

Affiliations

¹ Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
² Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

PMID: 37309608
PMCID: PMC10393075 (available on 2024-06-13)
DOI: 10.1093/eurheartj/ehad326

Abstract

Graphical Abstract

A potential mediatory role for systemic inflammation in the association between subclinical atherosclerosis and Grim epigenetic age acceleration, identified by multi-omics analyses utilizing participants in the Progression of Early Subclinical Atherosclerosis (PESA) study.

Publication types

Editorial
Research Support, N.I.H., Extramural
Comment

MeSH terms

Atherosclerosis* / epidemiology
Atherosclerosis* / genetics
Epigenesis, Genetic / genetics
Humans
Inflammation / genetics
Multiomics*

Grants and funding

HL151684/NH/NIH HHS/United States