Clinical Equivalence of Monoglyde® and Monocryl® Absorbable Poliglecaprone-25 Sutures: A Single-Blind, Randomized Study

Mpa Sailakshmi; Sukanta Misra; Sathyashree Hs; Soukhin Acharya; Ashok K Moharana; Deepak Ts

doi:10.7759/cureus.38938

Clinical Equivalence of Monoglyde® and Monocryl® Absorbable Poliglecaprone-25 Sutures: A Single-Blind, Randomized Study

Cureus. 2023 May 12;15(5):e38938. doi: 10.7759/cureus.38938. eCollection 2023 May.

Authors

Mpa Sailakshmi¹, Sukanta Misra², Sathyashree Hs¹, Soukhin Acharya², Ashok K Moharana³, Deepak Ts³

Affiliations

¹ Obstetrics and Gynecology, RajaRajeswari Medical College and Hospital, Bengaluru, IND.
² Obstetrics and Gynecology, Ramakrishna Mission Seva Pratishthan Vivekananda Institute of Medical Sciences, Kolkata, IND.
³ Clinical Affairs, Healthium Medtech, Bengaluru, IND.

Abstract

Objectives: Poliglecaprone-25 is a synthetic monofilament suture commonly used for post-cesarean subcuticular skin closure. The present study was designed to assess the effect of subcuticular skin closure using Monoglyde® vs. Monocryl® poliglecaprone-25 absorbable sutures on the risk of wound composite outcomes in the first 30 days post-partum [surgical site infection (SSI), wound dehiscence, hematoma or seroma].

Study design: This is a prospective, single-blind, randomized (1:1), multicentric, two-arm study performed between September 2020 and December 2021 at two different centers across India. Women (18-40 years) with a singleton pregnancy requiring cesarean delivery were randomized to Monoglyde® (n=62) or Monocryl® (n=62) suture groups. The primary endpoint is the incidence of wound composite outcomes in the first 30 days post-partum (SSI, wound dehiscence, seroma, or hematoma). In addition, the secondary outcomes, incidence of wound composite outcome at all visits (till four months), suture extrusion and loosening, suture removal and evaluation of microbial deposits on sutures (in case not absorbed or infection), operative time, intraoperative suture handling, postoperative pain, return to normal day-to-day activities, modified Hollander cosmesis score, subject satisfaction score, and adverse events were noted.

Results: Non-significant difference between the groups regarding demographic characteristics and primary endpoint; the incidence of wound composite outcome was observed. Moreover, no significant difference in suture extrusion and loosening, suture removal and evaluation of microbial deposits on sutures, operative time, intraoperative suture handling, pain, return to normal day-to-day activities, modified Hollander cosmesis, and subject satisfaction score were registered between the groups.

Conclusions: This study establishes the clinical equivalence of Monoglyde® and Monocryl® poliglecaprone-25 sutures, and both sutures can be used for subcuticular skin closure following cesarean delivery with minimal risk for wound complications.

Keywords: cesarean delivery; pain score; poliglecaprone-25 suture; subcuticular suturing; wound composite outcome.

Associated data

figshare/10.6084/m9.figshare.20398890.v1

Grants and funding

Authors MPA Sailakshmi, Sukanta Misra, Sathyashree HS, and Soukhin Acharya declare no conflict of interest. Authors Ashok Kumar Moharana and Deepak TS are full-time employees of Healthium Medtech, India (Manufacturers of Monoglyde® suture).