MALDI-ISD mass spectrometry analysis as a simple and reliable tool to detect post-translational modifications of hemoglobin variants: the case of Hb Raleigh

Clin Chem Lab Med. 2023 Jun 12;61(12):e251-e254. doi: 10.1515/cclm-2023-0442. Print 2023 Nov 27.

Authors

Selene De Benedittis^{1

2}, Patrizia Spadafora¹, Marco Gaspari³, Gabriele Qualtieri⁴, Olivier Gallo¹, Gemma Di Palma¹, Francesca Cavalcanti¹, Luigi Citrigno¹, Antonio Qualtieri¹

Affiliations

¹ National Research Council, Institute for Biomedical Research and Innovation (IRIB), Cosenza , Italy.
² Department of Medical and Surgical Sciences, University "Magna Graecia ", Germaneto, Catanzaro, Italy.
³ Research Centre for Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.
⁴ U.O.C Hematology, Annunziata Hospital, Cosenza, Italy.

PMID: 37307396
DOI: 10.1515/cclm-2023-0442

No abstract available

Keywords: hemoglobin variant; in-source decay; mass spectrometry; post-translational modification.

Publication types

Letter

MeSH terms

Amino Acid Sequence
Hemoglobins, Abnormal* / genetics
Humans
Protein Processing, Post-Translational
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods

Substances

hemoglobin Raleigh
Hemoglobins, Abnormal