Determination of Exogenous Adrenaline Levels in Patients Undergoing Cardiopulmonary Resuscitation

Mehmet Altuntaş; Derya Bal Altuntaş; Sema Aslan; Ersin Yılmaz; Ercan Nalbant

doi:10.1021/acsomega.3c00555

Determination of Exogenous Adrenaline Levels in Patients Undergoing Cardiopulmonary Resuscitation

ACS Omega. 2023 May 25;8(22):19425-19432. doi: 10.1021/acsomega.3c00555. eCollection 2023 Jun 6.

Authors

Mehmet Altuntaş¹, Derya Bal Altuntaş², Sema Aslan³, Ersin Yılmaz⁴, Ercan Nalbant¹

Affiliations

¹ Faculty of Medicine, Department of Emergency Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey.
² Faculty of Engineering and Architecture, Department of Bioengineering, Recep Tayyip Erdogan University, Rize 53100, Turkey.
³ Department of Chemistry, Faculty of Science, Muğla Sıtkı Koçman University, Muğla 48170, Turkey.
⁴ Department of Statistics, Muğla Sıtkı Koçman University, Muğla 48170, Turkey.

Abstract

Core-shell quantum dot ZnS/CdSe screen-printed electrodes were used to electrochemically measure human blood plasma levels of exogenous adrenaline administered to cardiac arrest patients. The electrochemical behavior of adrenaline on the modified electrode surface was investigated using differential pulse voltammetry (DPV), cyclic voltammetry, and electrochemical impedance spectroscopy (EIS). Under optimal conditions, the linear working ranges of the modified electrode were 0.001-3 μM (DPV) and 0.001-300 μM (EIS). The best limit of detection for this concentration range was 2.79 × 10^-8 μM (DPV). The modified electrodes showed good reproducibility, stability, and sensitivity and successfully detected adrenaline levels.