Immune response plays a role in Mycoplasma pneumoniae pneumonia

Front Immunol. 2023 May 26:14:1189647. doi: 10.3389/fimmu.2023.1189647. eCollection 2023.

Abstract

Introduction: Mycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the specific pathogenesis of the progression of Mycoplasma pneumoniae pneumonia (MPP) is unclear. We aimed to reveal the landscape of microbiota and the host immune response in MPP.

Methods: This self-controlled study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from the severe side (SD) and opposite side (OD) of 41 children with MPP from January to December 2021 and revealed the differences of the peripheral blood neutrophil function among children with mild MPP, severe MPP, and healthy children through transcriptome sequencing.

Results: The MP load or the pulmonary microbiota had no significant difference between the SD group and OD group, and the deterioration of MPP was related to the immune response, especially the intrinsic immune response.

Discussion: The immune response plays a role in MPP, which may inform treatment strategies for MPP.

Keywords: Mycoplasma pneumoniae; Mycoplasma pneumoniae pneumonia; microbiome; the immune response; transcriptome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bronchoalveolar Lavage Fluid
  • Child
  • Humans
  • Microbiota*
  • Mycoplasma pneumoniae
  • Neutrophils
  • Pneumonia, Mycoplasma*

Grants and funding

This study was supported by the General Program of National Natural Science Foundation of China (82270008), Grants from Jiangsu Province Special Funds for Key Program (Social Development) (BE2019607), the Youth Program of National Natural Science Foundation of China (82200008), the Major Program of Wuxi health and Family Planning Commission (Z202016), and the Wuxi Maternal and Child Health Research Project (FYKY202003). Vision Medicals Center for Infectious Diseases (Guangdong, China) was responsible for part of the sequencing and bioinformatics analysis of this research.